His analysis interests revolve around investigating immune regulation and dysregulation during the context of HIV infection or publicity. He focuses on Immune ontogeny in HIV uncovered infants, placental investigations and pre-phrase birth, and epithelial immunity while in the foreskin. He has an active team within the IDM and relies at Stellenbosch College wherever he directs the Reproductive Immunology Analysis Consortium in Africa . To be a collective, the analysis teams contain around 440 analysis officers and laboratory, scientific, area web-site and administrative support personnel, 280 Masters and PhD learners registered in any 12 months, and sixty or more Postdoctoral Fellows. He is undoubtedly an HIV and TB immunologist centered on studying the immune response to these pathogens in influenced tissues, and how this relates to what could be noticed within the blood.

Her Study Unit is involved with medical investigate, epidemiology and operational research, and it is a treatment method web-site for HIV contaminated Older people and children. Her study interests contain HIV vaccine investigation, microbicide exploration and other biomedical and behavioural interventions, and she is definitely an investigator in testing two HIV vaccine regimens in late stage scientific development. His research is centered on improved understanding HIV transmission and disease dynamics with a special focus on HIV superinfection, latent HIV an infection, along with the position in the virus in HIV+ organ transplantation.

He is an author on over a hundred and fifty manuscripts in the sphere of infectious conditions and has an intensive history in infectious conditions analysis and practice masking medical, laboratory and epidemiological aspects. Her investigate concentrates on comprehending the role with the building immune system to the susceptibility of younger children to tuberculosis and knowledge the function of innate and adaptively obtained CD8+ T cells in host defense to TB. The translational importance of this exploration is centred on informing the development of novel vaccines and diagnostics for childhood TB.

The investigate aim is to further improve knowledge of the immunopathology of TB and HIV, applying this data to help in building novel therapeutic strategies and diagnostic biomarkers. Analysis desire in tuberculosis and in establishing and tests stage of treatment diagnostics suitable for the building environment. Areas of curiosity span The essential sciences of chemistry, biochemistry and microbiology, via to pharmacology and medical medication, during the areas of mycobacterial pathogenesis and TB drug discovery analysis.